Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma

Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma

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Abstract A 73-year-old man with a history of marginal zone lymphoma was admitted to the emergency room for grandpas best diplopia and ipsilateral headache.The Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) demonstrated intense and symmetrical hypermetabolism of the cavernous sinuses, and hypermetabolic lesions diffusely in the lymph nodes and bones.The diagnosis of high-grade relapse of lymphomatous disease was made.In this context, the homogenous and symmetric lesion of the cavernous sinuses, without any other encephalic or meningeal lesions, raised the hypothesis of a paraneoplastic origin.A plausible paraneoplastic link between the neuro-ophthalmological lesion and the malignant disorder is IgG4-related disease, a condition that may be associated with lymphoma.

As in our koip share price case, this diagnosis is often presumptive because histopathological confirmation is difficult to obtain.